Axonis Therapeutics

Overview

Axonis Therapeutics is a Boston-based biotechnology company focused on developing innovative medicines for neurological disorders. The company specializes in targeting KCC2, a key mediator of inhibitory neurotransmission in the brain. Its mission is to restore functional inhibition in the central nervous system to address conditions like epilepsy and chronic pain, where existing therapies often fall short.

Founded on scientific discoveries from Boston Children’s Hospital, Harvard University, and Laval University, the organization utilizes a proprietary KCC2 discovery engine to create oral KCC2 potentiator drugs. Its lead candidate, AXN-027, is currently in first-in-human clinical trials and aims to improve treatment outcomes for patients by overcoming impaired synaptic inhibition. The company has secured substantial financial support, including a $115 million Series A financing round in October 2024, reflecting strong investor confidence in its technology and pipeline. It is committed to providing new treatment options for patients suffering from neurological disorders, particularly those with epilepsy and chronic pain.

Basic Information

Industry	biotechnology
Founded	2019
Revenue	2M
Headquarters	75 Kneeland St, 14th Floor, Boston, Massachusetts 02111, United States

Contact Details

Website: axonis.us
LinkedIn: linkedin.com/company/axonis-us

Key Focus Areas & Initiatives

Drug discovery for neurological disorders
KCC2 potentiator development
Targeting impaired synaptic inhibition in epilepsy and chronic pain
First-in-human clinical trials (AXN-027)
Neuro-regeneration and neuroprotection research
Innovative oral therapeutics
Neuro-focused biotechnology development
Animal models for CNS diseases
Translational research from scientific discoveries

Technologies Used

AI
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IoT
Microsoft Office 365
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Outlook
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